Alex Willoughby , aged 17, who is from Cowley, was last seen in Verbena Way, Oxford, at about 9pm on Tuesday 14 November.

Alex is a white girl, 5ft 7ins, slim with blonde wavy hair and blue eyes.

Investigating officer, Inspector Mark Brock said: “We are becoming increasingly concerned for Alex Willoughby’s welfare and therefore we are publishing an appeal and asking anyone with information to please make contact with police.

“Alex is from Oxford but also has links to Kent. It is possible that Alex has used public transport in the last week so I would ask anyone travelling on buses or trains to be vigilant and keep an eye out for her.

“If anyone has any information about Alex’s whereabouts please call the 24-hour Thames Valley Police enquiry centre on 101 and quote reference number 43170339604.

“If you do not want to speak directly to the police you can contact the independent charity Crimestoppers anonymously on 0800 555 111.”